Serotonergic dysfunction may mediate the relationship between alcohol consumption and Alzheimer's disease.

Pierson SR, Kolling LJ, James T, Selvakumar GP, Marcinkeiwcz CA.  Pharmacol Res, 203 (2024). DOI: 10.1016/j.phrs.2024.107171

Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood

Kanza M. Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Govindhasamy Pushpavathi Selvakumar, Ruixiang Wang, Suzanne Mason, Michael E. Dailey, Catherine A. Marcinkiewcz. Brain, Behavior, and Immunity, Volume 107, 2023, Pages 419-431, ISSN 0889-1591, DOI: 10.1016/j.bbi.2022.07.160.

Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease.

Khan KM, Balasubramanian N, Gaudencio G, Wang R, Govindhasamy S, Pierson S, Tadinada S, Abel T, Hefti M, Marcinkiewcz C. Acta neuropathol commun 11, 57 (2023). DOI: 10.1186/s40478-023-01546-5

Repeated ethanol exposure and withdrawal alters angiotensin-converting enzyme 2 expression in discrete brain regions: Implications for SARS-CoV-2 neuroinvasion.

Balasubramanian N, James TD, Selvakumar GP, Reinhardt J, Marcinkiewcz CA. Alcohol Clin Exp Res (Hoboken). 2023 Feb;47(2):219-239. doi: 10.1111/acer.15000. Epub 2023 Jan 1. PMID: 36529893; PMCID: PMC9878009.

Sex-Dependent Modulation of Anxiety and Fear by 5-HT_1A Receptors in the Bed Nucleus of the Stria Terminalis

Catherine A. Marcinkiewcz, Gabrielle Bierlein-De La Rosa, Cayce E. Dorrier, Mackenzie McKnight, Jeffrey F. DiBerto, Dipanwati Pati, Carol A. Gianessi, Olivia J. Hon, Greg Tipton, Zoe A. McElligott, Eric Delpire, and Thomas L. Kash. ACS Chemical Neuroscience 2019 10 (7), 3154-3166. DOI: 10.1021/acschemneuro.8b00594

Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala.

Marcinkiewcz CA, Mazzone CM, D’Agostino G,  Halladay LR, Hardaway JA, DiBerto JF, Navarro M, Burnham N, Cristiano C, Dorrier CE, Tipton GJ, Ramakrishnan C, Kozicz T, Deisseroth K, Thiele T, McElligott ZA, Holmes A, Heisler LK and Kash TL. 2016.  Nature537(7618):97-101.

Serotonin's Complex Role in Alcoholism: Implications for Treatment and Future Research. 

Marcinkiewcz C, Lowery-Gionta E, Kash T. 2016. Alcohol Clin Exp Res 40(6):1192-1201.

Chronic EtOH effects on putative measures of compulsive behavior in mice. 

Radke A., Jury N, Kocharian A, Marcinkiewcz C, Lowery-Gionta E, Pleil K, McElligott Zoe, McKlveen J, Kash T, Holmes A. Addiction Biology 2015 Dec 21. doi: 10.1111/adb.12342

A robust behavioral program and network of activation is encoded by activating dorsal raphe serotonergic neurons. 

Urban DJ, Zhu H, Marcinkiewcz CA, Michaelides M, Oshibuchi H, Rhea D, Aryal DK, Farrell MS, Lowery-Gionta E, Olsen RHJ, Wetsel WC, Kash TL, Hurd YL, Tecott LH, and Roth BL. 2016. Neuropsychopharmacology 41(5):1404-15.

Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward. 

Al-Hasani R, McCall JG, Shin G, Gomez AM, Schmitz GP, Bernardi JM, Pyo CO, Park SI, Marcinkiewcz CA, Crowley NA, Krashes MJ, Lowell BB, Kash TL, Rogers JA, Bruchas MR. 2015. Neuron 87(5):1063-77.

Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala.

Pleil KE, Lowery-Gionta EG, Crowley NA, Li C, Marcinkiewcz CA, Rose JH, McCall NM, Maldonado-Devincci AM, Morrow AL, Jones SR, Kash TL. 2015. Neuropharmacology 99:735-49.

Serotonergic systems in the pathophysiology of ethanol dependence: Relevance to clinical alcoholism.

Marcinkiewcz, CA. 2015. ACS Chemical Neuroscience 6(7): 1026-39.

Modulation of OCT3 gene expression by stress, and antidepressant-like activity of decynium-22 in an animal model of depression.

Marcinkiewcz, CA and Devine DP. 2015.  Pharmacology, Biochemistry and Behavior 131: 33-41.

Neuropeptide Regulation of Signaling and Behavior in the BNST.

Kash TL, Pleil KE, Marcinkiewcz CA, Lowery-Gionta EG, Crowley N, Mazzone C, Sugam J, Hardaway A, McElligott ZA. 2014.  Molecules and Cells 38(1): 1-13.

Ethanol induced adaptations in 5-HT2C receptor signaling in the bed nucleus of the stria terminalis: Implications for anxiety during ethanol withdrawal. 

Marcinkiewcz CA, Dorrier CE, Lopez AJ, Kash TL. 2014. Neuropharmacology 89C: 157-167.

Functional alterations in the dorsal raphe nucleus following acute and chronic ethanol exposure. 

Lowery-Gionta EG, Marcinkiewcz CA, Kash TL. 2014. Neuropsychopharmacology40(3):590-600.

Chronic alcohol remodels prefrontal neurons and disrupts NMDA receptor-mediated fear extinction encoding. 

Holmes A, Fitzgerald PJ, MacPherson KP, DeBrouse L, Pleil KE, Masneuf S, Li C, Flynn S, Marcinkiewcz CA, Colacicco G, Gunduz-Cinar O, Kash TK and Camp M. 2012. Nature Neuroscience 15(10):1359-61.

Social defeat stress potentiates thermal sensitivity in operant models of pain processing. 

Marcinkiewcz CA, Duarte P, Devine DP, Vierck CJ and Yezierski RP. 2009. Brain Research 1251:112-120.

Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats. 

Marcinkiewcz CA, Prado MM, Isaac SK, Marshall A, Rylkova D and Bruijnzeel AW. 2009. Neuropsychopharmacology 34(7):1743-52.

The effects of buprenorphine on fentanyl withdrawal in rats. 

Bruijnzeel AW, Marcinkiewcz C, Isaac S, Booth MM, Dennis DM, Gold MS. 2007. Psychopharmacology (Berl)191(4):931-941.